WinPOPT

 

Optimization for Population PKPD Study Design

 

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Publications


WinPOPT:

  • Zamuner S, Gomeni R. Optimal Design to Estimate the Time Varying Receptor Occupancy Relationship in a PET Experiment.  PAGE 16 (2007) Abstr 1099 [www.page-meeting.org/?abstract=1099]
  • Petrone M, Zamuner S, Di Iorio V, Gunn R, Laruelle M, Gomeni R.  Model-based sequential human PET study design for Optimal PK/RO assessment.  PAGE 16 (2007) Abstr 1183 [www.page-meeting.org/?abstract=1183]
  • Mentré F, Duffull S, Gueorguieva I, Hooker A, Leonov S, Ogungbenro K, Retout S.  Software for optimal design in population PKPD: a comparison.  PAGE 16 (2007) Abstr 1179 [www.page-meeting.org/?abstract=1179]
  • Green B, Kirkpatrick CM, McLeay S, Morrish G,  Lean Bodyweight as a Descriptor for Propofol Clearance.  AAPS Meeting 2007.
  • McGree JM, Duffull SB, Eccleston JA, Ward LC.  Optimal designs for studying bioimpedance Physiol Meas 2007; 28: 1465–1483
  • Denman N, Mould D, Duffull S. Study Designs to Assess the Placebo Response (PBO-R) for Hamilton Depression (HAMD) Scores for Depression.  AAPS Poster 2006.
  • Mould D, Denman N, Duffull S. Using disease progression models as a tool to detect drug effect Clin Pharmacol Ther 2007; 82:81-86

POPT:

  • McGree JM, Duffull SB, Eccleston JA, Ward LC.  Optimal designs for studying bioimpedance Physiol Meas 2007; 28: 1465–1483
  • Zhou S, Pfister M, Roy A.  Optimal Sampling design and trial simulation using POPT and NONMEM.  ASCEPT Conference 2007.
  • Zhou S, Pfister M, Roy A.  Optimal Sampling design and trial simulation using POPT and NONMEM.  PAGE 16 (2007) Abstr 1215 [www.page-meeting.org/?abstract=1215]
  • Hennig, S., Waterhouse, T.H., Bell, S.C., France, M., Wainwright, C.E., Miller, H., Charles, B.G. and Duffull, S.B. A D-optimal designed population pharmacokinetic study of oral itraconazole in adult cystic fibrosis patients.  BJCP (accepted 2006)
  • Duffull, S.B., Waterhouse, T.H. and Eccleston, J.A. Some considerations on the design of population pharmacokinetic studies.J. Pharmacokinetic Pharmacodyn. 2005; 32:441-457
  • Waterhouse, T.H., Redmann, S., Duffull, S.B. and Eccleston, J.A. Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients.J. Pharmacokinetic Pharmacodyn. 2005; 32:521-545
  • Green, B. and Duffull, S.B. Prospective evaluation of a D-optimal designed population pharmacokinetic study. J. Pharmacokinetic Pharmacodyn. 2003; 30:145-161
  • Duffull, S.B., Retout, S. and Mentré, F. The use of simulated annealing for finding optimal population designs. Comp. Methods Programs Biomed. 2002; 69:25-35.
  • Duffull, S.B., Mentré, F. and Aarons, L. Optimal design of a population pharmacodynamic experiment for ivabradine. Pharm. Res. 2001; 18:83-89.
     


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